Real Physiology Series Episode 2: Introducing ACT 1 & ACT 2
- Featuring |
- Featuring |
- July 20 2026
- Duration 1: 17: 17
In this episode of the Real Physiology Series, Dr. Allen Jeremias and Dr. Rasha Al-Lamee explore how coronary physiology has evolved from a diagnostic tool for ischemia detection into a critical component of procedural planning and optimization. Through a candid, expert-to-expert discussion, they introduce the ACT 1 & ACT 2 framework, demonstrating how physiology, co-registration, and intravascular imaging can work together to guide lesion assessment, personalize PCI strategy, optimize treatment decisions, and evaluate procedural success.
At-a-glance:
- [2:49] The Evolving Role of Physiology in PCI
- [6:42] Introducing the ACT 1 Framework
- [9:08] ACT 2: Optimizing Results After PCI
- [10:00] Standardizing PCI Through Physiology-Guided Care
This episode of the Real Physiology Series features Dr. Allen Jeremias and Dr. Rasha Al-Lamee discussing how coronary physiology has evolved from a diagnostic tool into a key component of PCI planning and optimization. They introduce the ACT 1 and ACT 2 framework, demonstrating how physiology, co-registration, and intravascular imaging work together to guide treatment decisions before and after intervention.
The conversation highlights how identifying focal versus diffuse disease enables more personalized and effective PCI strategies while minimizing unnecessary stenting. The physicians also explore the role of post-PCI physiological assessment in identifying opportunities to further optimize procedural outcomes.
Drawing on current research and clinical experience, they discuss how emerging evidence is shaping the future of physiology-guided intervention and standardized care. Throughout the discussion, they emphasize that integrating physiology, imaging, and advanced planning tools can improve consistency, efficiency, and ultimately patient outcomes.
I think if you can have both (physiology and imaging) if you can have two, you want both, right? Of course, there are cost constraints in some systems where that’s not possible. In my system I am able to use both as liberally as I like and for me if I had PCI that’s what I’d want the interventionalist to do.
Dr. Rasha Al-Lamee
Copy this URLto share this story with your professional network
Disclaimer
Results are specific to the institution where they were obtained and may not reflect the results achievable at other institutions. Results in other cases may vary.